Calcein Release from Temperature-Sensitive Liposome with OR without Stirring.
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چکیده
منابع مشابه
Temperature-sensitive liposome-mediated delivery of thrombolytic agents.
BACKGROUND Clinical efficacy of thrombolytic drugs is limited by lack of specific delivery and requires large therapeutic doses which increase toxicity. Encapsulating these drugs in temperature-sensitive liposomes and applying hyperthermia to deliver thrombolytic agents locally to thrombus might theoretically favourably alter the therapeutic window. The objectives of this study were to formulat...
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A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH(4)HCO(3) gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO(2) gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.
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today hydrogels are considered as the materials that are able to play important role in drug delivery systems. to design an effective hydrogel applicable network, mathematical modeling has a critical role. a successful drug delivery device relies not only on intelligent network design but also on accurate prior mathematical modeling of drug release profiles. in this study, the modeling of the i...
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Lysolipid temperature-sensitive liposomes (LTSLs) demonstrate enhanced release of encapsulated drug contents via grain boundary permeabilization when heated to their phase transition temperature, resulting in dramatic in vivo tumor toxicity. Dithionite ion permeability and doxorubicin release were measured for lysolipid and nonlysolipid containing membranes to characterize and attempt to determ...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1994
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.17.166